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Cirion Foundation

the impact of infectious diseases

TREVI studies

HIV infection manifests itself differently in different populations, in different 'shades' as it were. These shade differences can be seen particularly in the various long-term effects of HIV infection in general and vascular damage in particular.

This first study instigated a follow-up study in which Lennert van den Dries is currently involved. Lennert is studying the link between the HIV virus and the brain in both adults and in children. Based on the findings that I have just shared with you, the hypothesis is that the increased risk of thrombosis with HIV infection could also be the cause of vascular damage and possibly microinfarction, small blood clots, in the brain. The brain forms a reservoir where the HIV virus can hide. Because of this, chronic HIV infection can potentially affect the brain, which, in clinical practice, may lead to cognitive functional disorders such as loss of concentration. This may lead to problematic functioning in social and work situations and may have serious consequences for the quality of life of HIV patients. Obviously, loss of capacity for work may also have negative economic effects. The TREVI study investigates all of these aspects. The study has been set up by various departments of Erasmus Medical Centre in collaboration with the Chronic Disease and Labour knowledge centre of the Rotterdam University of Applied Sciences, the Institute for Policy and Management in Health Care, and Sophia Children's Hospital in Rotterdam. Lennert van den Dries, Marlies Wagener and Stefanie van Opstal are the PhD's who are working together in this project. The TREVI study is an outstanding example of translational research, from bench to bedside to society.

Research team:

o Prof. Eric C.M. van Gorp

o Lennert van den Dries MD

o Rob Gruters Msc

o Marlies Wagener

o Stefanie van Opstal